Uzedy 50 mg/0.14 ml syringe with external subcutaneous suspension (2023)

1948drug name

generic name:
Risperidone - subcutaneous injection


brand names)
Perseris, Uzedy


There may be a slightly increased risk of serious and potentially fatal side effects (such as stroke, heart failure, fast/irregular heartbeat, pneumonia) when this medicine is used in elderly people with dementia. This drug is not approved to treat dementia-related behavioral problems. Discuss with your doctor the risks and benefits of this medicine, as well as other effective and possibly safer treatments for behavioral problems associated with dementia.


Risperidone is used to treat a certain mental/mood disorder called schizophrenia. This drug can reduce hallucinations, help you think more clearly and positively about yourself, feel less aroused, and participate more actively in everyday life.

Risperidone is an antipsychotic (atypical) medicine. It works by helping to restore the balance of certain natural substances in the brain.

How to use

This medicine is given by injection under the skin of the abdomen or in the arm by a healthcare professional. It is given as prescribed by the doctor. Depending on the brand, this drug is usually given once every 1 to 2 months. It is used to replace the oral administration of risperidone. Do not take the medicine by mouth when injecting subcutaneously.

Before each dose is injected, the injection site will be cleaned with isopropyl alcohol. The injection should not be given into an area of ​​skin that is irritated, red, bruised, infected or scarred. The site should be changed each time to reduce damage under the skin. You may have a lump at the injection site for several weeks. This lump will shrink over time. Do not rub or massage the injection site. Try not to wear belts or belts over the bump.

Dosage depends on your medical condition, response to treatment, and other medications you are taking. Be sure to tell your doctor and pharmacist about all the products you use (including prescription, over-the-counter, and herbal products).

You must take this drug regularly to get the most benefit from it. To help you remember, mark your calendar so you know when your next dose is. Continue to take this medicine even if you feel well.

Tell your doctor if your condition does not improve or worsens.

Side effects

Drowsiness, dizziness, vertigo, constipation, fatigue, drooling, weight gain, or redness/pain at the injection site may occur. If any of these symptoms persist or worsen, tell your doctor or pharmacist immediately.

Dizziness and vertigo can increase the risk of falling. Get up slowly from a sitting or lying position.

Please note that you have been prescribed this medicine because your doctor has decided that the benefits to you outweigh the risk of side effects. Many people taking this drug do not experience serious side effects.

Tell your doctor right away if you experience any serious side effects, including:

  • Difficulty swallowing
  • contracting
  • tremble (tremble)
  • mental/mood changes (such as anxiety, restlessness)
  • intermittent breathing during sleep

This drug may rarely increase blood sugar levels, which may cause or worsen diabetes. Tell your doctor straight away if you experience symptoms of high blood sugar, such as increased thirst/urination. If you already have diabetes, check your blood sugar regularly as directed and share the results with your doctor. Your doctor may need to adjust your diabetes medications, exercise program, or diet.

This drug can also cause significant weight gain and an increase in the level of cholesterol (or triglycerides) in the blood. These effects, along with diabetes, can increase the risk of developing heart disease. Discuss the risks and benefits of treatment with your doctor. (See also the Notes section.)

Risperidone may rarely cause a condition called tardive dyskinesia. In some cases, this condition may be permanent. Tell your doctor straight away if you experience unusual/uncontrollable movements (especially of the face, lips, mouth, tongue, arms or legs).

This medicine may increase the levels of a certain natural substance (prolactin) produced by the body. For women, this increase in prolactin can lead to unwanted breast milk, missed/stopped periods, or difficulty getting pregnant. For men, this can lead to reduced sexual ability, an inability to produce sperm, or breast enlargement. If any of these symptoms occur, tell your doctor immediately.

Get medical help right away if you experience very serious side effects, including:

  • severe dizziness
  • to faint
  • attack

This drug may rarely cause a very serious condition called neuroleptic malignant syndrome (NMS). Get medical help right away if you experience any of the following symptoms:

  • fever
  • muscle stiffness/pain/tenderness/weakness
  • severe fatigue
  • serious mess
  • Lighthouse
  • fast/irregular heartbeat
  • dark urine
  • signs of kidney problems (such as changes in the amount of urine)

Rarely, men may experience a painful or prolonged erection that lasts 4 hours or more. If this happens, stop using this medicine and seek medical attention immediately, otherwise permanent problems may occur.

A very severe allergic reaction to this medicine is rare. However, seek medical attention right away if you notice any signs of a severe allergic reaction, including:

  • fever
  • enlarged lymph nodes
  • skin irritation
  • itching/swelling (especially of the face/tongue/throat)
  • severe dizziness
  • breathing difficulties

This is not a complete list of possible side effects. If you notice any other symptoms not listed above, consult your doctor or pharmacist.


Call your doctor for medical advice about side effects. Side effects can be reported to the FDA at 1-800-FDA-1088 or at

In Canada - Call your doctor for medical advice about side effects. Side effects can be reported to Health Canada at 1-866-234-2345.


Before taking risperidone, tell your doctor or pharmacist if you are allergic to it; or paliperidone; or if you have any other allergies. This product may contain inactive ingredients that may cause allergic reactions or other problems. Talk to your pharmacist for more information.

Before taking this medicine, tell your doctor or pharmacist about your medical history, especially of:

  • liver disease
  • kidney disease
  • attack
  • Difficulty swallowing
  • low number of white blood cells
  • Parkinson's disease
  • Insanity
  • some eye problems (cataracts, glaucoma)
  • personal or family history of diabetes
  • heart disease
  • high cholesterol/triglycerides
  • trouble breathing while sleeping (sleep apnea)

Risperidone can cause a condition that affects the rhythm of the heart (QT prolongation). QT prolongation can rarely cause severe (rarely fatal) rapid/irregular heartbeat and other symptoms (such as severe dizziness, fainting) that require immediate medical attention.

The risk of QT prolongation may be increased if you have certain medical conditions or are taking other medications that can cause QT prolongation. Before taking risperidone, tell your doctor or pharmacist of all the medicines you are taking and if you have any of the following conditions:

  • certain heart problems (heart failure, slow heartbeat, prolonged QT interval on EKG)
  • family history of certain heart problems (electrocardiogram QT prolongation, sudden cardiac death)

Low levels of potassium or magnesium in the blood may also increase the risk of QT prolongation. This risk may be increased if you are taking certain medications (such as diuretics/"water pills") or if you have a medical condition such as diaphoresis, diarrhoea, or vomiting. Talk to your doctor about using risperidone safely.

This medicine may cause dizziness or drowsiness. Alcohol or marijuana (cannabis) may cause dizziness or drowsiness. Do not drive, operate machinery or do anything that requires you to be alert until you can safely do so. Avoid alcoholic beverages. If you use marijuana (cannabis), talk to your doctor.

Before any surgery (including cataract/glaucoma eye surgery), tell your doctor or dentist that you are taking or taking this drug and all other products you use (including prescription, over-the-counter, and herbal products).

This drug may make you sweat less, making you more likely to experience heat stroke. Avoid things that can cause you to overheat, such as hard work, exercising in hot weather, or using a hot tub. If it's hot, drink plenty of fluids and dress lightly. If you overheat, quickly find a place to cool down and rest. Seek medical attention immediately if you have persistent fever, mental/mood changes, headache or dizziness.

Older adults may be more sensitive to the side effects of this drug, especially drowsiness, dizziness, vertigo, and QT prolongation (see above). Drowsiness, lightheadedness, and lightheadedness can increase your risk of falling.

During pregnancy, this medicine should only be used if clearly needed. Babies born to mothers who have taken this medicine in the last 3 months of pregnancy may rarely show symptoms such as muscle stiffness or tremors, drowsiness, difficulty eating/breathing, or incessant crying. If you notice any of these symptoms in your newborn, especially in the first month, tell your doctor right away.

Since untreated mental/mood problems (such as schizophrenia) can be a serious condition, do not stop taking this medicine unless directed to do so by your doctor. If you are planning to become pregnant, become pregnant, or suspect you may be pregnant, discuss the benefits and risks of taking this medication while pregnant with your doctor immediately.

This medicine passes into breast milk and may have undesirable effects on a nursing baby. Tell your doctor right away if your child develops symptoms such as muscle stiffness or tremors, unusual sleepiness, or trouble eating. Consult your doctor before feeding.

Drug interactions

Drug interactions can change the way drugs work or increase the risk of serious side effects. This document does not cover all possible drug interactions. Keep a list of all the products you use (including prescription, over-the-counter, and herbal products) and share it with your doctor and pharmacist. Do not start, stop or change the dosage of any medication without your doctor's approval.

A product that may interact with this drug is:

  • metoclopramide

Tell your doctor or pharmacist if you are taking other products that make you drowsy, such as opioid painkillers or cough medicines (such as codeine, hydrocodone), alcohol, marijuana (cannabis), sleeping pills or anti-anxiety medicines (such as alprazolam, lorazepam, zolpidem). muscle relaxants (such as carisoprodol, cyclobenzaprine) or antihistamines (such as cetirizine, diphenhydramine).

Check the labels of all your medications (such as allergy or cough and cold products) as they may contain ingredients that cause drowsiness. Ask your pharmacist how to use these products safely.


If someone has overdosed and has serious symptoms, such as fainting or difficulty breathing, call 911. If not, contact a poison control center right away. US residents can call their local poison control center at 1-800-222-1222. Canadian residents can call their provincial poison control center. Overdose symptoms may include severe drowsiness/dizziness, fast/irregular heartbeat, unusual/uncontrollable movements, convulsions.


Laboratory and/or medical tests (such as blood sugar, weight, blood pressure, blood cholesterol/triglycerides) should be performed while taking this medicine. Keep all doctor and lab appointments.

missed dose

It is important that you receive each dose of this medicine on time. If you miss a dose, ask your doctor or pharmacist immediately for a new dosing schedule.

Report tab

Not applicable. This medicine is given in a hospital or clinic and is not kept at home.

Important note

HOW TO USE THIS INFORMATION: This is a summary and does NOT contain all possible information about this product. This information does not guarantee that this product is safe, effective or suitable for you. This information does not constitute individual medical advice and does not replace the advice of a physician. Always ask your doctor for complete information about this product and your specific health needs.

Information last changed in May 2023.

Copyright(c) 2023 First Databank, Inc.


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